Advantages:

- tissular origine

- higher sensitivity and specificity in neoplastic differentiation between benigne and malignant lesion, border line lesions, degenerative processes, lysosomal storage disease and parasitic involvement

- margins evaluation of malignant tumors

- usual stain and special stain used for specific agents or degenerative disorders

- invasion and infiltration grade in tumoral evaluation

- vascular invasion

- metastatic capacity

- important rol in prognosis

Sampling methods are variable:

• Incisional biopsy (ultrasound guided when need): parenchimatous organs, cutaneous or subcutaneous , bone, skeletal muscle, skin

• Endoscopy, rhinoscopy, bronchoscopy

• Excizional biopsy: different body zones